Reviews on Recent Clinical Trials 2013-03-01

Clinical trials in irritable bowel syndrome: a review.

Claire M Ervin, Allen W Mangel

文献索引：Rev. Recent Clin. Trials 8(1) , 9-22, (2013)

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摘要

Irritable bowel syndrome (IBS) is one of the most common gastrointestinal disorders and it is characterized by episodes of abdominal pain and altered bowel functions. The specific bowel disturbances of diarrhea, constipation or an alternation between the two defines the IBS subtypes of diarrhea-predominant, constipation-predominant, and mixed or alternating IBS. Because of the abnormalities in bowel states associated with each IBS subtype, it is not likely that one agent would successfully treat all three subtypes. As a result, clinical trials have focused, for the most part, on one IBS subtype. Over the past 2 decades very few agents have achieved regulatory approval for the treatment of IBS. In the present article we review publications reporting on phase 2 and phase 3 studies evaluating agents to potentially be used in the treatment of patients with IBS.

相关化合物

  • 1,3,5-三甲氧基苯
  • 列腺素 E1
  • 盐酸阿洛司琼

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