Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis 1983-02-01

The biological activity of 4-chloromethylbiphenyl, benzyl chloride and 4-hydroxymethylbiphenyl in 4 short-term tests for carcinogenicity. A report of an individual study in the UKEMS genotoxicity trial 1981.

S C Booth, A J Mould, A Shaw, R C Garner

文献索引：Mutat. Res. 119(2) , 121-33, (1983)

全文：HTML全文

摘要

4-Chloromethylbiphenyl (4CMB), benzyl chloride (BC) and 4-hydroxymethyl-biphenyl (4HMB) were tested for biological activity in the following assays: (i) the Salmonella/microsome assay; (ii) a bacterial 'fluctuation' assays; (iii) a DNA repair assay in Hela cells, and (iv) a mouse lymphoma mutation assay. 4CMB was active in assays (i), (ii) and (iii) but not in (iv); BC was active in assays (i), (ii), (iii) but not in (iv) while 4HMB was inactive in all assays. Where biological activity was seen this did not require addition of a liver S9 preparation. 4CMB was more active than BC in all the test systems in which a positive response was obtained. The implication of these results for a test battery approach to in vitro testing is discussed.

相关化合物

  • 4-联苯甲醇
  • 4-氯甲基联苯

相关文献：

UKEMS trial compounds: induction of unscheduled DNA synthesis in HeLa S3 cells.

1982-01-01

[Mutat. Res. 100(1-4) , 207-9, (1982)]

An assay for mutagenic activity of 4CMB, 4HMB and BC, using the "microtitre" fluctuation test.

1982-01-01

[Mutat. Res. 100(1-4) , 81-5, (1982)]

Mutation at the TK locus of mouse lymphoma L5178Y cells by 4CMB, 4HMB and BC.

1982-01-01

[Mutat. Res. 100(1-4) , 249-51, (1982)]

The cytotoxic and mutagenic effects of 4CMB, BC and 4HMB in V79 Chinese hamster cells.

1982-01-01

[Mutat. Res. 100(1-4) , 239-44, (1982)]

A comparison of the response of BHK21 C13 cells to 4-chloromethylbiphenyl, 4-hydroxymethylbiphenyl and benzyl chloride in a cell transformation test.

1982-01-01

[Mutat. Res. 100(1-4) , 223-6, (1982)]

更多文献...