Journal of Pharmaceutical and Biomedical Analysis 1999-03-01

Photodegradation of folic acid in aqueous solution.

M J Akhtar, M A Khan, I Ahmad

文献索引：J. Pharm. Biomed. Anal. 19 , 269-275, (1999)

全文：HTML全文

摘要

A study of the photodegradation of folic acid by ultraviolet radiation in aqueous solution has been made. Folic acid is photolysed by an apparent first-order kinetics and the log k-pH profile shows a gradual decrease in rate in the pH range 2.0-10.0. The profile indicates the appearance of three steps which reflect the participation of different ionic species of folic acid (pKa(1) 2.3, pKa(2) 8.3) in the photolysis reaction. The rate of photodegradation varies from 0.1550 x 10(-3) min(-1) (pH 10.0) to 5.04 x 10(-3) min(-1) (pH 2.5) in the pH range studied. The photolysis of folic acid shows that it is degraded to pterine-6-carboxylic acid and p-amino-benzoyl-L-glutamic acid. A maximum yield of these products is obtained at 3-8 h, depending upon the pH. An HPLC method has been used for the assay of folic acid and its degradation products.

相关化合物

  • N-(4-氨基甲酰)-L-...
  • 2-氨基-4-氧代-3,4-...

相关文献：

Simultaneous quantification of 21 water soluble vitamin circulating forms in human plasma by liquid chromatography-mass spectrometry.

2015-11-27

[J. Chromatogr. A. 1422 , 89-98, (2015)]

Kinetic model of folate metabolism in nonpregnant women consuming [2H2]folic acid: isotopic labeling of urinary folate and the catabolite para-acetamidobenzoylglutamate indicates slow, intake-dependent, turnover of folate pools.

1998-11-01

[J. Nutr. 128(11) , 1896-906, (1998)]

Purification and properties of a folate-catabolizing enzyme.

2000-11-10

[J. Biol. Chem. 275(45) , 35646-55, (2000)]

Quantitation of folates and their catabolites in blood plasma, erythrocytes, and urine by stable isotope dilution assays.

2010-03-15

[Anal. Biochem. 398(2) , 150-60, (2010)]

Kinetics of folate turnover in pregnant women (second trimester) and nonpregnant controls during folic acid supplementation: stable-isotopic labeling of plasma folate, urinary folate and folate catabolites shows subtle effects of pregnancy on turnover of folate pools.

2001-07-01

[J. Nutr. 131(7) , 1928-37, (2001)]

更多文献...