Archives of Pharmacal Research
2001-02-01
Monoamine oxidase B inhibitors from the fruits of Opuntia ficus-indica var. saboten.
Y N Han, Y Choo, Y C Lee, Y I Moon, S D Kim, J W Choi
文献索引:Arch. Pharm. Res. 24(1) , 51-4, (2001)
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摘要
Three varieties of methyl citrate and 1-methyl malate were isolated from the fruits of Opuntia ficus-indica var. saboten Makino through in vitro bioassay-guided isolation for the inhibition on monoamine oxidase(MAO). The IC50 values for MAO-B of 1-monomethyl citrate, 1,3-dimethyl citrate, trimethyl citrate and 1-methyl malate were 0.19, 0.23, 0.61 and 0.25 mM, respectively. However, on MAO-A, their inhibitions showed only marginal activity.
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