Designing of peptide substrates. Different approaches exemplified by new chromogenic substrates for kallikreins and urokinase.
G Claeson, L Aurell, P Friberger, S Gustavsson, G Karlsson
文献索引:Haemostasis 7 , 62, (1978)
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摘要
Chromogenic peptide substrates for serine proteases have been designed by using two approaches: (1) by using the natural substrate as a model and (2) by structure-activity correlations obtained through screening of a large number of tripeptides. Some recent examples, substrates for kallikreins and urokinase are given.
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