Research communications in chemical pathology and pharmacology 1988-04-01

Effect of some new prostaglandin synthetase inhibitors on the endotoxin induced mortality and biochemical changes in experimental animals.

M Tariq

文献索引：Res. Commun. Chem. Pathol. Pharmacol. 60(1) , 19-25, (1988)

全文：HTML全文

摘要

The protective effect of some novel nonsteroidal anti-inflammatory agents has been studied on the endotoxin (lipopolysaccharide B) shock induced mortality in mice and biochemical changes in rats. All the three compounds included in this report, namely isoxicam, fentiazac and ketoprofen have been found to produce significant protection against the endotoxin mortality in mice. Isoxicam and fentiazac have been found effective in antagonizing some of the biochemical changes induced by endotoxin in rats. On the other hand isoxicam and ketoprofen exacerbated the increase in serum aminotransferases induced by endotoxin. It is suggested that mechanisms other than the prostaglandin synthetase inhibition may be involved in the protective effect of these drugs.

相关化合物

  • 伊索昔康

相关文献：

[The effect of estro-progesterones on the inflammatory episodes of hand arthroses. Apropos of a case].

1989-10-01

[Rev. Rhum. Mal. Osteoartic. 56(10) , 709-11, (1989)]

Controlled-release naproxen compared with isoxicam in patients with osteoarthritis.

1988-01-01

[Curr. Med. Res. Opin. 11(1) , 28-33, (1988)]

In vivo metabolism of isoxicam in rats, dogs, and monkeys.

1989-01-01

[Drug Metab. Dispos. 17(6) , 662-8, (1989)]

Liquid chromatography-tandem mass spectrometry method for the determination of meloxicam and its metabolite 5-carboxymeloxicam in human plasma.

2009-04-01

[Bioanalysis 1(1) , 63-70, (2009)]

In vitro metabolism of isoxicam by horseradish peroxidase.

1989-12-01

[Xenobiotica 19(12) , 1369-77, (1989)]

更多文献...