Electroorganic synthesis of new benzofuro[2,3-d]pyrimidine derivatives.
Davood Nematollahi, Hassan Goodarzi
文献索引:J. Org. Chem. 67(14) , 5036-39, (2002)
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摘要
Electrochemical oxidation of 3,4-dihydroxybenzoic acid (1) in the presence of 1,3-dimethylbarbituric acid (2) and 1,3-diethyl-2-thiobarbituric acid (3) as nucleophiles in aqueous solution has been studied using cyclic voltammetry and controlled-potential coulometry. The results indicate that 1 via Michael reaction under electro-decarboxylation reaction converts to benzofuro[2,3-d]pyrimidine derivatives (6a, 6b). The electrochemical synthesis of 6a, 6b has been successfully performed in an undivided cell in good yields and purity.
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