Novel binuclear chiral zirconium catalysts used in enantioselective strecker reactions.
S Kobayashi, H Ishitani
文献索引:Chirality 12(5-6) , 540-3, (2000)
全文:HTML全文
摘要
A novel binuclear chiral zirconium catalyst was successfully used in enantioselective Strecker reactions. The catalyst was readily prepared from zirconium t-butoxide (Zr(OtBu)4), (R)-6,6'-dibromo-1, 1'-bi-2-naphthol ((R)-6-Br-BINOL), and (R)-3,3'-dibromo-1, 1'-bi-2-naphthol ((R)-3-Br-BINOL) to form unique binuclear structure. It was revealed that a combination of (R)-6-Br-BINOL and (R)-3-Br-BINOL was essential in these asymmetric reactions and that much lower selectivities were obtained by using other combinations. Two-component (an imine and hydrogen cyanide (HCN)) and three-component (an aldehyde, an amine, and HCN) Strecker reactions proceeded smoothly in the presence of a catalytic amount of the chiral zirconium catalyst to afford the corresponding alpha-amino nitrile derivatives in high yields with high enantioselectivities.Copyright 2000 Wiley-Liss, Inc.
相关化合物
相关文献:
2009-05-07
[J. Phys. Chem. A 113(18) , 5423-31, (2009)]
Diastereoselective and enantioselective glyoxylate-ene reaction catalyzed by new class of binaphthol-derived titanium complex. Terada M, et al.
[Tetrahedron Lett. 35(36) , 6693-6696, (1996)]