International Journal of Molecular Sciences
2012-01-01
Improved synthesis of 5-substituted 1H-tetrazoles via the [3+2] cycloaddition of nitriles and sodium azide catalyzed by silica sulfuric acid.
Zhenting Du, Changmei Si, Youqiang Li, Yin Wang, Jing Lu
文献索引：Int. J. Mol. Sci. 13(4) , 4696-703, (2012)
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摘要
A silica supported sulfuric acid catalyzed [3+2] cycloaddition of nitriles and sodium azide to form 5-substituted 1H-tetrazoles is described. The protocol can provide a series of 5-substituted 1H-tetrazoles using silica sulfuric acid from nitriles and sodium azide in DMF in 72%-95% yield.
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