Journal of chromatography. A 2015-08-07

Cyclodextrin clicked chiral stationary phases with functionalities-tuned enantioseparations in high performance liquid chromatography.

Yuzhou Lin, Jie Zhou, Jian Tang, Weihua Tang

文献索引:J. Chromatogr. A. 1406 , 342-6, (2015)

全文:HTML全文

摘要

In this work, two cyclodextrin (CD) chiral stationary phases (CSPs) have been developed by clicking per-4-chloro-3-methylphenylcarbamoylated mono-6(A)-azido-β-CD (CSP1) and per-5-chloro-2-methylphenylcarbamoylated mono-6(A)-azido-β-CD (CSP2) onto alkynylated silica support. The enantioslectivies of the as-obtained new CSPs have been evaluated using 29 model racemates including aromatic alcohols, flavonoids, β-blocker and FMOC-amino acids in both reversed-phase (RP) and normal-phase (NP) high performance liquid chromatography (HPLC). The CD functionalities tuned enantioselectivities were elucidated in different HPLC elution modes. Higher chiral resolutions were achieved in RP-elution mode with the aid of the inclusion complexation in comparison to NP-elution mode. The π-π stacking interaction and dipole-dipole interaction provided by phenylcarbamate moieties can also contribute to the enantioseparation. Copyright © 2015 Elsevier B.V. All rights reserved.


相关化合物

  • 5-氯-2-甲基苯基异...

相关文献:

Influence of HDL-cholesterol-elevating drugs on the in vitro activity of the HDL receptor SR-BI.

2007-08-01

[J. Lipid Res. 48(8) , 1832-45, (2007)]

The vibrational spectra, assignments and ab initio/DFT analysis for 3-chloro, 4-chloro and 5-chloro-2-methylphenyl isocyanates. Doddamani SB, et al.

[Spectrochim. Acta. A. Mol. Biomol. Spectrosc. 67(1) , 150-159, (2007)]

更多文献...