Synthesis and pharmacology of 1-deoxy analogs of CP-47,497 and CP-55,940.
John W Huffman, Alicia L S Thompson, Jenny L Wiley, Billy R Martin
文献索引：Bioorg. Med. Chem. 16 , 322-35, (2008)
全文：HTML全文
摘要
A series of 1-deoxy analogs of CP-47,497 (8 and 13, n=0-7) and 1-deoxy analogs of CP-55,940 (9, n=0-7) have been synthesized and their affinities for the cannabinoid CB(1) and CB(2) receptors have been determined. Although the majority of these compounds exhibit selectivity for the CB(2) receptor, none have greater than modest affinity for either receptor. The interactions of these 1-deoxy nontraditional cannabinoids with the CB(2) receptor are discussed.
相关化合物
相关文献：
2006-03-31
[J. Org. Chem. 71(7) , 2825-8, (2006)]
Novel non-symmetric nickel-diimine complexes for the homopolymerization of ethene: Control of branching by catalyst design. Schmid M, et al.
[Z. Naturforsch. B 57(10) , 1141-46, (2002)]