[Teratologic studies of methyl 5-aminosalicylate and salicylazopyridine].

J M Xiong, B Liang, Y Q Mo, Z H Chen

文献索引：Zhongguo Yao Li Xue Bao 13(3) , 265-7, (1992)

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摘要

Methyl 5-aminosalicylate hydrochloride (M-5-AS) at the dosages of 21, 42, 209, and 417 mg.kg-1.d-1 ig to mice during d 6-15 of pregnancy, no obvious effects on the placenta, fetus weight, sex differentiation, external appearance, visceral, and skeletal development were observed. In rats ig M-5-AS 56 and 556 mg.kg-1.d-1 produced no noticeable effects on the organogenesis or teratogenesis either. In mice and rats ig salicylazopyridine 410 and 1089 mg.kg-1.d-1 respectively no obvious teratogenicity was detected. However, aspirin 250 mg.kg-1.d-1 ig did bring about significant teratogenicity in rats.