Biotransformation of heterocyclic dinitriles by Rhodococcus erythropolis and fungal nitrilases.
Vojtech Vejvoda, Ondrej Sveda, Ondrej Kaplan, Vera Prikrylová, Veronika Elisáková, Michal Himl, David Kubác, Helena Pelantová, Marek Kuzma, Vladimír Kren, Ludmila Martínková
文献索引：Biotechnol. Lett. 29(7) , 1119-24, (2007)
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摘要
2,6-Pyridinedicarbonitrile (1a) and 2,4-pyridinedicarbonitrile (2a) were hydrated by Rhodococcus erythropolis A4 to 6-cyanopyridine-2-carboxamide (1b; 83% yield) and 2-cyanopyridine-4-carboxamide (2b; 97% yield), respectively, after 10 min. After 118 h, the intermediates 1b or 2b were transformed into 2,6-pyridinedicarboxamide (1c; 35% yield) and 2,6-pyridinedicarboxylic acid (1d; 60% yield) or 2-cyanopyridine-4-carboxylic acid (2c; 64% yield), respectively. The nitrilase from Fusarium solani afforded cyanocarboxylic acids 1e and 2c after 118 h (yields 95 and 62%, respectively). 3,4-Pyridinedicarbonitrile (3a) and 2,3-pyrazinedicarbonitrile (4a) were inferior substrates of nitrile hydratase and nitrilase.
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