Annals of Emergency Medicine 1992-12-01

Simpson's paradox and clinical trials: what you find is not necessarily what you prove.

N S Abramson, S F Kelsey, P Safar, K Sutton-Tyrrell

文献索引：Ann. Emerg. Med. 21(12) , 1480-2, (1992)

全文：HTML全文

摘要

Expensive clinical trials have become the gold standard for evaluating the efficacy of promising new therapeutic agents. Full exploration of the collected data is routine to maximize the yield of the information available. However, potential methodologic flaws in these extensive analyses may not be appreciated by investigators or readers. One such problem with subgroup analyses is discussed, using hypothetical examples and data from a recently completed clinical trial of brain resuscitation as illustrations.

相关化合物

  • 利多氟嗪

相关文献：

Protective effects of the lazaroid U74500A and lidoflazine on liver preservation with UW solution.

1993-01-01

[Transpl. Int. 6(5) , 281-4, (1993)]

1,4-Dihydropyridines bearing a pharmacophoric fragment of lidoflazine.

1996-10-01

[Bioorg. Med. Chem. 4(10) , 1629-35, (1996)]

Effects of lidoflazine on left ventricular function in patients.

1997-02-01

[J. Cardiothorac. Vasc. Anesth. 11(1) , 42-8, (1997)]

The pathophysiology of angina pectoris and the effect of lidoflazine.

1982-01-01

[Circulation 65(1 Pt 2) , I27-32, (1982)]

Lidoflazine and myocardial protection.

1995-05-01

[J. Thorac. Cardiovasc. Surg. 109(5) , 1013-4; discussion 1015, (1995)]

更多文献...