Bioorganic & Medicinal Chemistry 1996-10-01

1,4-Dihydropyridines bearing a pharmacophoric fragment of lidoflazine.

A Chiarini, A Rampa, R Budriesi, A Bisi, G Fabbri, P Valenti

文献索引：Bioorg. Med. Chem. 4(10) , 1629-35, (1996)

全文：HTML全文

摘要

A series of 1,4-dihydropyridines bearing a pharmacophoric fragment of lidoflazine was synthesized. The compounds were evaluated for inotropic, chronotropic, and calcium antagonist activities. All compounds behave as inotropic and chronotropic agents, except for compounds 4b, 5a, and 5b, which exhibit a rather weak calcium antagonism in vascular smooth muscle (like aorta). Compound 5b is about twofold more potent in decreasing both chronotropy and inotropy, while compound 5c is about fivefold more potent in decreasing inotropy than nifedipine. Moreover, compound 5b is the most potent calcium antagonist derivative of the series.

相关化合物

  • 利多氟嗪

相关文献：

Protective effects of the lazaroid U74500A and lidoflazine on liver preservation with UW solution.

1993-01-01

[Transpl. Int. 6(5) , 281-4, (1993)]

Simpson's paradox and clinical trials: what you find is not necessarily what you prove.

1992-12-01

[Ann. Emerg. Med. 21(12) , 1480-2, (1992)]

Effects of lidoflazine on left ventricular function in patients.

1997-02-01

[J. Cardiothorac. Vasc. Anesth. 11(1) , 42-8, (1997)]

The pathophysiology of angina pectoris and the effect of lidoflazine.

1982-01-01

[Circulation 65(1 Pt 2) , I27-32, (1982)]

Lidoflazine and myocardial protection.

1995-05-01

[J. Thorac. Cardiovasc. Surg. 109(5) , 1013-4; discussion 1015, (1995)]

更多文献...