Fundamental and Applied Toxicology 1991-08-01

Difference in the developmental toxicity of ethylenethiourea and three N,N'-substituted thiourea derivatives in rats.

A M Saillenfait, J P Sabate, I Langonne, J de Ceaurriz

文献索引：Fundam. Appl. Toxicol. 17(2) , 399-408, (1991)

全文：HTML全文

摘要

Sprague-Dawley rats were administered ethylenethiourea (ETU), 1,3-dimethyl-2-thiourea (DMT), 1,3-dibutyl-2-thiourea (DBT), or 1,3-diphenyl-2-thiourea (DPT) by gavage from Days 6 to 20 of gestation. Daily dosage levels (mg/kg/day) were ETU at 0, 15, 25 and 35; DMT at 0, 15, 25, 50, 100, and 200; DBT at 0, 15, 25, 50, 100, and 200; and DPT at 0, 25, 50, 100, and 200. There was evidence of maternal toxicity at all doses of DMT and at doses greater than or equal to 50 mg DBT/kg/day. DPT was embryolethal at 200 mg/kg/day. Fetotoxicity was observed at doses greater than or equal to 15 mg DMT/kg/day, greater than or equal to 15 mg DBT/kg/day, and greater than or equal to 100 mg DPT/kg/day. ETU was the only chemical tested that proved to be teratogenic.

相关化合物

  • 二苯基硫脲
  • N,N'-二丁基硫脲

相关文献：

Occupational rubber glove allergy: results of the Information Network of Departments of Dermatology (IVDK), 1995-2001.

2003-01-01

[Contact Dermatitis 48(1) , 39-44, (2003)]

Study of a reaction between 2,3-dichloro-1,4-naphthoquinone and N,N'-diphenyl thiourea involving an EDA adduct as intermediate.

1993-01-01

[Spectrochim. Acta. A. Mol. Biomol. Spectrosc. 60(7) , 1641-7, (2004)]

Diphenylthiourea, a common rubber chemical, is bioactivated to potent skin sensitizers.

2011-01-14

[Chem. Res. Toxicol. 24(1) , 35-44, (2011)]

Contact allergy to IPPD and diphenylthiourea in an orthopaedic brace.

2001-11-01

[Contact Dermatitis 45(5) , 301-2, (2001)]

The guinea-pig skin sensitization test revisited: an evaluation formula to predict possible sensitization levels for eight chemicals used in household products.

1998-02-20

[Toxicology 126(1) , 75-82, (1998)]

更多文献...