Memorias do Instituto Oswaldo Cruz 2009-08-01

Preparation and antitubercular activity of lipophilic diamines and amino alcohols.

Celso O R Júnior, Mireille le Hyaric, Cristiane F da Costa, Taís A Corrêa, Aline F Taveira, Débora P Araújo, Elaine F C Reis, Maria Cristina S Lourenço, Felipe R C Vicente, Mauro V de Almeida

文献索引：Mem. Inst. Oswaldo Cruz 104(5) , 703-5, (2009)

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摘要

A series of diamines and amino alcohols derived from 1-dodecanol, 1-tetradecanol, 1,2-dodecanediol and 1,2-tetradecanediol were synthesized and tested for their antitubercular activity. Compounds 3, 8 and 9 were found to be the most active (MIC of 6.25 microg/mL). Nine other compounds displayed activity against Mycobacterium tuberculosis, with a MIC of 12.5 microg/mL.

相关化合物

  • 1,2-十二烷二醇

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