Discovery of new chemotype dipeptidyl peptidase IV inhibitors having (R)-3-amino-3-methyl piperidine as a pharmacophore

Yukihiro Nishio, Hidenori Kimura, Shinya Tosaki, Eiji Sugaru, Mutsuko Sakai, Masakuni Horiguchi, Yumi Masui, Michiko Ono, Tsutomu Nakagawa, Hiroyuki Nakahira, Yukihiro Nishio, Hidenori Kimura, Shinya Tosaki, Eiji Sugaru, Mutsuko Sakai, Masakuni Horiguchi, Yumi Masui, Michiko Ono, Tsutomu Nakagawa, Hiroyuki Nakahira, Yukihiro Nishio, Hidenori Kimura, Shinya Tosaki, Eiji Sugaru, Mutsuko Sakai, Masakuni Horiguchi, Yumi Masui, Michiko Ono, Tsutomu Nakagawa, Hiroyuki Nakahira

文献索引：Bioorg. Med. Chem. Lett. 20 , 7246-7249, (2010)

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摘要

The new chemotype DPP-IV inhibitors, such as compound 7c (IC 50 = 27 nM), is herein reported.