Acta Crystallographica Section B 2008-12-01

Chiral carboxylic acids and their effects on melting-point behaviour in co-crystals with isonicotinamide.

Andreas Lemmerer, Nikoletta B Báthori, Susan A Bourne

文献索引：Acta Crystallogr. B 64(Pt 6) , 780-90, (2008)

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摘要

The crystal structures of co-crystals of two systems of chiral carboxylic acids, optically active and racemic 2-phenylpropionic acid and 2-phenylbutyric acid, with isonicotinamide are reported to investigate the effects of the chirality of the chiral carboxylic acids on the melting point of the co-crystal complexes. It was found that the racemic co-crystal has a higher melting point than the optically active co-crystal, which correlates with the denser packing arrangement inherent in centrosymmetric space groups.

相关化合物

  • 2-苯基丙酸
  • (|S|)-(+)-2-苯丙酸
  • R-2-苯基丙酸
  • α-甲基氢肉桂酸
  • 异烟碱

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