Journal of Organic Chemistry 2011-03-18

A synthesis of acetamidines.

Jitendra R Harjani, Chen Liang, Philip G Jessop

文献索引：J. Org. Chem. 76(6) , 1683-91, (2011)

全文：HTML全文

摘要

The condensation of primary amine with N,N-dimethylacetamide dimethyl acetal yields a mixture of acetamidine and imidate ester. The product distribution in this reaction depends on the temperature, solvent, and structure of the primary amine. It is possible to suppress the formation of imidate ester by performing the reaction in the presence of excess dimethyl amine, yielding acetamidine as the exclusive product. For acetamidines that cannot be purified either by crystallization or distillation, this new method is necessary for the generation of pure acetamidines in good yields.

相关化合物

  • 乙缩醛二甲醇
  • 乙脒盐酸盐

相关文献：

One-pot enol silane formation-Mukaiyama aldol-type addition to dimethyl acetals mediated by TMSOTf.

2008-04-18

[J. Org. Chem. 73(8) , 3299-302, (2008)]

An expeditious synthesis of 4-hydroxy-2E-nonenal (4-HNE), its dimethyl acetal and of related compounds.

2007-12-01

[Chem. Phys. Lipids 150(2) , 239-43, (2007)]

Matrix isolation infrared and ab initio study of the conformations of 2,2-dimethoxypropane.

2003-05-01

[Spectrochim. Acta. A. Mol. Biomol. Spectrosc. 59(7) , 1497-507, (2003)]

Hybrid Lithium-Sulfur Batteries with a Solid Electrolyte Membrane and Lithium Polysulfide Catholyte.

2015-08-05

[ACS Appl. Mater. Interfaces 7 , 16625-31, (2015)]

Mice lacking mitochondrial ferritin are more sensitive to doxorubicin-mediated cardiotoxicity.

2014-08-01

[J. Mol. Med. 92(8) , 859-69, (2014)]

更多文献...