Determination of piroxicam and its major metabolites in the plasma, urine and bile of humans by high-performance liquid chromatography.

P A Milligan

文献索引：J. Chromatogr. A. 576(1) , 121-8, (1992)

全文：HTML全文

摘要

A simple and sensitive liquid chromatographic method with ultraviolet detection is described for the determination of the nonsteroidal anti-inflammatory drug piroxicam and its major metabolites in human plasma, urine and bile. Separation of these components occurs on a reversed phase C10CN column with a mobile phase consisting of acetonitrile-water-sodium dihydrogenphosphate solution. The detection limit of the assay was 50 ng/ml with intra- and inter-assay coefficients of variation for piroxicam of the order of 2 and 5%, respectively. The assay linearity was good (typically r = 0.9999). This method can be readily utilised for clinical pharmacokinetic and mass-balance studies.

相关化合物

  • 5-羟基吡罗昔康

相关文献：

[The binding of oxicam derivatives to human serum albumin].

1988-08-01

[Arzneimittelforschung 38(8) , 1089-92, (1988)]

High-performance liquid chromatographic analysis of piroxicam and its major metabolite 5'-hydroxypiroxicam in human plasma and urine.

[J. Chromatogr. A. 382 , 382-8, (1986)]

Extractionless high-performance liquid chromatographic method for the simultaneous determination of piroxicam and 5'-hydroxypiroxicam in human plasma and urine.

1995-11-03

[J. Chromatogr. B, Biomed. Appl. 673(1) , 142-6, (1995)]

Simultaneous determination of piroxicam and its major metabolite 5'-hydroxypiroxicam in human plasma by derivative spectrophotometry.

1998-08-01

[Analyst 123(8) , 1749-52, (1998)]

Determination of piroxicam and its major metabolite 5-hydroxypiroxicam in human plasma by zero-crossing first-derivative spectrophotometry.

1998-07-01

[J. Pharm. Biomed. Anal. 17(3) , 515-24, (1998)]

更多文献...