Efficient and improved synthesis of Telmisartan.
A Sanjeev Kumar, Samir Ghosh, G N Mehta
文献索引：Beilstein J. Org. Chem. 6 , 25, (2010)
全文：HTML全文
摘要
An efficient synthesis of the angiotensin II receptor antagonist Telmisartan (1) is presented involving a cross coupling of 4-formylphenylboronic acid 10 with 2-(2-bromophenyl)-4,4-dimethyl-2-oxazoline (11) as the key step (90% yield). The benzimidazole moiety 15 was constructed regioselectively via a reductive amination-condensation sequence, replacing the alkylation of the preformed benzimidazole step in the previously published route. This methodology overcomes many of drawbacks associated with previously reported syntheses.
相关化合物
相关文献：
2008-08-19
[Langmuir 24(16) , 8711-8, (2008)]
2008-01-01
[Acta Crystallogr. Sect. E Struct. Rep. Online 64(Pt 6) , o1141, (2008)]
[Synthesis , 1273, (1992)]
Recent developments in use of heteropolyacids, their salts and polyoxometalates in organic synthesis. Heravi MM and Sadjadi S.
[J. Iranian Chem. Soc. 6(1) , 1-54, (2009)]