International Journal of Nanomedicine 2012-01-01

Targeted delivery of Tet1 peptide functionalized polymersomes to the rat cochlear nerve.

Ya Zhang, Weikai Zhang, Alexander H Johnston, Tracey A Newman, Ilmari Pyykkö, Jing Zou

文献索引：Int. J. Nanomedicine 7 , 1015-22, (2012)

全文：HTML全文

摘要

Polymersomes are nanosized vesicles formed from amphiphilic block copolymers, and have been identified as potential drug delivery vehicles to the inner ear. The aim of this study was to provide targeting to specific cells within the inner ear by functionalizing the polymersome surface with Tet1 peptide sequence. Tet1 peptide specifically binds to the trisialoganglioside clostridial toxin receptor on neurons and was expected to target the polymersomes toward the cochlear nerve. The Tet1 functionalized PEG-b-PCL polymersomes were administered using routine drug delivery routes: transtympanic injection and cochleostomy. Delivery via cochleostomy of Tet1 functionalized polymersomes resulted in cochlear nerve targeting; in contrast this was not seen after transtympanic injection.

相关化合物

  • 神经节苷脂GT1b三...
  • 4-硝基苯酯碘乙酸

相关文献：

Botulinum neurotoxin G binds synaptotagmin-II in a mode similar to that of serotype B: tyrosine 1186 and lysine 1191 cause its lower affinity.

2013-06-04

[Biochemistry 52(22) , 3930-8, (2013)]

Distribution of mono-, di- and trisialo gangliosides in the brain of Actinopterygian fishes

2012-09-01

[Biochim. Biophys. Acta 1820(9) , 1437-43, (2012)]

Gangliosides prevent glutamate and kainate neurotoxicity in primary neuronal cultures of neonatal rat cerebellum and cortex.

1988-10-01

[Proc. Natl. Acad. Sci. U. S. A. 85 , 7351-7355, (1988)]

GM1 / GD1b / GA1 synthase expression results in the reduced cancer phenotypes with modulation of composition and raft-localization of gangliosides in a melanoma cell line.

2010-09-01

[Cancer Sci. 101(9) , 2039-47, (2010)]

Botulinum neurotoxins B and E translocate at different rates and exhibit divergent responses to GT1b and low pH.

2012-07-17

[Biochemistry 51(28) , 5655-62, (2012)]

更多文献...