Journal of the American Chemical Society 2010-03-24

A highly efficient palladium/copper cocatalytic system for direct arylation of heteroarenes: an unexpected effect of Cu(Xantphos)I.

Jinkun Huang, Johann Chan, Ying Chen, Christopher J Borths, Kyle D Baucom, Robert D Larsen, Margaret M Faul

文献索引：J. Am. Chem. Soc. 132 , 3674, (2010)

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摘要

Heteroarenes are important structural moieties in many chemical industry fields. A highly efficient Pd/Cu-catalyzed C-H arylation method for a range of heterocycles has been discovered. It was found that the key to the success of this transformation is a combination of a palladium catalyst and a well-defined copper cocatalyst. The efficiency and low loadings of catalyst (0.25 mol %) and cocatalyst (1 mol %) together with the mild reaction conditions demonstrate this method to be practically useful and mechanistically interesting.