Oligophenylenaminones as scaffolds for α-helix mimicry.
Marc J Adler, Andrew D Hamilton
文献索引:J. Org. Chem. 76(17) , 7040-7, (2011)
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摘要
The design and synthesis of small molecule α-helix mimetics has been a productive field over the past decade. These compounds have performed well in a variety of biological systems as functional disruptors of α-helix-mediated protein-protein interactions. In our studies we have continued to develop novel, more biologically compatible scaffolds, which are often easier to assemble and capable of mimicking longer and/or more diverse helices. To this end, we have constructed a new series of i, i+4, i+7 α-helix mimics based on the enaminone scaffold. These molecules represent a step forward in the pursuit of idealized monofacial α-helix mimetics.
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2003-10-20
[Bioorg. Med. Chem. Lett. 13(20) , 3597-600, (2003)]