Journal of the American Chemical Society 2007-05-16

Gas-phase tautomeric equilibrium of 4-hydroxypyrimidine with its ketonic forms: a free jet millimeterwave spectroscopy study.

Raquel Sanchez, B Michela Giuliano, Sonia Melandri, Laura B Favero, Walther Caminati

文献索引：J. Am. Chem. Soc. 129(19) , 6287-90, (2007)

全文：HTML全文

摘要

4-Hydroxypyrimidine (4HP) has two conformational forms (the hydroxyl hydrogen cis or trans with respect to the adjacent nitrogen), which are in tautomeric equilibrium with two ketonic forms, 4-pyrimidinone (4PO) and 6-pyrimidinone (6PO). We have investigated the free jet absorption millimeterwave spectrum of this system, assigning the rotational spectra of 4HPcis and 4PO; the latter species is more stable by 2.0(9) kJ/mol. No lines corresponding to the trans isomer of 4-hydroxypyridine and to 6PO have been observed.

相关化合物

  • 4-嘧啶酮

相关文献：

Tautomerism in 4-hydroxypyrimidine, S-methyl-2-thiouracil, and 2-thiouracil.

2010-12-09

[J. Phys. Chem. A 114(48) , 12725-30, (2010)]

Synthesis and biological activity of N(4)-phenylsubstituted-6-(2,4-dichloro phenylmethyl)-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamines as vascular endothelial growth factor receptor-2 inhibitors and antiangiogenic and antitumor agents.

2010-05-15

[Bioorg. Med. Chem. 18(10) , 3575-87, (2010)]

Kinetic isotope effects and electron transfer in the reduction of xanthine oxidoreductase with 4-hydroxypyrimidine. A comparison between oxidase and dehydrogenase forms.

1997-09-05

[J. Biol. Chem. 272(36) , 22514-25, (1997)]

更多文献...