Pharmazie 1991-06-01

[The separation of some racemic beta-blockers and alpha-sympathomimetics with HPLC following derivatization].

T Jira, C Toll, C Vogt, T Beyrich

文献索引：Pharmazie 46(6) , 432-4, (1991)

全文：HTML全文

摘要

Five beta-adrenergic blocking agents and two alpha-sympathicomimetics were separated after derivatization with (R)-(-)-1-(Naphth-1-yl)-ethylisocyanate (NEIC). For two of these analytes the separation was successful also after reaction with (R)-(+)-1-phenylethylisocyanate (PEIC) by using HPLC with RP-18 phases and a water-methanolic eluent by UV-detection on 254 nm. After reaction with (1S)-(+)-campher-10-sulfonylchloride (CSC) an acceptable separation of norphenylephedrine also was possible. Analytes which can be derivated with NEIC and PEIC give no reaction with CSC (and vice versa).

相关化合物

  • 异氰酸(R)-(-)-1-(...
  • 2-苯乙基异氰酸酯

相关文献：

Enantiomeric analysis of phenylpropanolamine in plasma via resolution of dinitrophenylurea derivatives on a high performance liquid chromatographic chiral stationary phase.

1991-01-01

[Biomed. Chromatogr. 5(1) , 43-6, (1991)]

Stereospecific high-performance liquid chromatographic assay of sotalol in plasma.

1991-09-01

[Pharm. Res. 8(9) , 1195-8, (1991)]

Stereospecific high-performance liquid chromatographic determination of tocainide.

[J. Chromatogr. A. 566(1) , 155-62, (1991)]

Enantioselective analysis of sotalol in plasma by reversed-phase high-performance liquid chromatography using diastereomeric derivatives.

1995-10-06

[J. Chromatogr. B, Biomed. Appl. 672(1) , 89-96, (1995)]

Chiral high-performance liquid chromatographic determination of oxprenolol in plasma.

[J. Chromatogr. A. 621(2) , 225-9, (1993)]

更多文献...