Organic Letters
2008-12-18
In situ "click" assembly of small molecule matrix metalloprotease inhibitors containing zinc-chelating groups.
Mingyu Hu, Junqi Li, Shao Q Yao
文献索引:Org. Lett. 10(2) , 5529-5531, (2008)
全文:HTML全文
摘要
A panel of small molecule-based MMP inhibitors containing rhodanine warheads was assembled using "one-pot" click chemistry. Upon biological screening, moderate inhibitors were identified which specifically targets MMP-7 and MMP-13 over other MMPs.
相关化合物
相关文献:
Decomposition of halogen-substituted phenyl azides Smalley, R. K. and Suschitzky, H.
[J. Chem. Soc. , 5922-5925, (1964)]