Fully automated continuous flow synthesis of 4,5-disubstituted oxazoles.
Marcus Baumann, Ian R Baxendale, Steven V Ley, Christoper D Smith, Geoffrey K Tranmer
文献索引:Org. Lett. 8 , 5231, (2006)
全文:HTML全文
摘要
[Structure: see text] A multipurpose mesofluidic flow reactor capable of producing gram quantities of material has been developed as an automated synthesis platform for the rapid on-demand synthesis of key building blocks and small exploratory libraries. The reactor is configured to provide the maximum flexibility for screening of reaction parameters that incorporate on-chip mixing and columns of solid supported reagents to expedite the chemical syntheses.
相关化合物
相关文献:
2006-08-23
[J. Am. Chem. Soc. 128 , 10662, (2006)]
1993-04-16
[J. Med. Chem. 36 , 1001, (1993)]
2012-12-28
[Chem. Commun. (Camb.) 48(100) , 12228-30, (2012)]
[Tetrahedron Lett. 35 , 2493, (1994)]
[Tetrahedron Lett. 34 , 5463, (1993)]