Aryl urea analogs with broad-spectrum antibacterial activity.
Punit P Seth, Ray Ranken, Dale E Robinson, Stephen A Osgood, Lisa M Risen, Elizabeth L Rodgers, Michael T Migawa, Elizabeth A Jefferson, Eric E Swayze
文献索引：Bioorg. Med. Chem. Lett. 14(22) , 5569-72, (2004)
全文：HTML全文
摘要
The preparation and evaluation of novel aryl urea analogs as broad-spectrum antibacterial agents is described. Numerous compounds showed low micromolar minimum inhibitory concentrations (MIC) against both Gram-positive and Gram-negative bacteria. Selected analogs also exhibited in vivo efficacy in a lethal murine model of bacterial septicemia.
相关化合物
相关文献：
2013-03-18
[Chemistry 19(12) , 3842-5, (2013)]
Synthesis and luminescence characteristics of conjugated dendrimers with 2, 4, 6-triaryl-1, 3, 5-triazine periphery. Kim CK, et al.
[J. Polym. Sci. A Polym. Chem. 44(1) , 254-263, (2006)]
Synthesis, crystal structures, and antibacterial activity of a series of hydrazone compounds derived from 4-methylbenzohydrazide. Lei Y, et al.
[J. Chil. Chem. Soc. 60(2) , 2961-2965, (2015)]
Coordination-Driven Self-Assembly of Fullerene-Functionalized Pt (II) Metallacycles. Neti VSPK, et al.
[Organometallics 34(20) , 4813-4815, (2015)]
Conformational Behavior of Conjugated Polymers With Oligo (phenylene vinylene) Side Chains. Peeter H and Koeckelberghs G.
[Macromol. Chem. Phys. 214(5) , 538-546, (2013)]