Method for the biological monitoring of hexahydrophthalic anhydride by the determination of hexahydrophthalic acid in urine using gas chromatography and selected-ion monitoring.

B Jönsson, G Skarping

文献索引：J. Chromatogr. A. 572(1-2) , 117-31, (1991)

全文：HTML全文

摘要

A method for the determination of hexahydrophthalic acid, a metabolite of hexahydrophthalic anhydride, in human urine has been developed. The urine was worked-up by liquid-solid extraction, esterified with boron trifluoride-methanol, and analysed by capillary gas chromatography and selected-ion monitoring. Hexadeuterium-labelled hexahydrophthalic acid was used as the internal standard. The precision was 4% at 0.7 microgram/ml and 5% at 0.07 microgram/ml. The recovery of the acid for the overall method was 101% at 0.07 micrograms/ml of urine (with a coefficient of variation of 4%) and 95% at 0.7 microgram/ml (coefficient of variation 2%). The limit of detection was 20 ng/ml urine.

相关化合物

  • 反-1,2-环己烷二甲...

相关文献：

Determination of hexahydrophthalic acid and methylhexahydrophthalic acid in plasma after derivatisation with pentafluorobenzyl bromide using gas chromatography and mass spectrometric detection.

1997-04-11

[J. Chromatogr. B. Biomed. Sci. Appl. 691(2) , 331-9, (1997)]

Toxicokinetics and biological monitoring in experimental exposure of humans to gaseous hexahydrophthalic anhydride.

1993-06-01

[Scand. J. Work. Environ. Health 19(3) , 183-90, (1993)]

Generation of hexahydrophthalic anhydride atmospheres in a controlled human-use test chamber.

1994-04-01

[Am. Ind. Hyg. Assoc. J. 55(4) , 330-8, (1994)]

Occupational exposure to hexahydrophthalic anhydride: air analysis, percutaneous absorption, and biological monitoring.

1993-01-01

[Int. Arch. Occup. Environ. Health 65(1) , 43-7, (1993)]

Methods for the identification of chemical respiratory allergens in rodents: comparisons of cytokine profiling with induced changes in serum IgE.

2003-01-01

[J. Appl. Toxicol. 23(4) , 199-207, (2003)]

更多文献...