Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis 1990-12-01

Influence of DNA repair deficiencies on the UV sensitivity of yeast cells in different cell cycle stages.

W Siede, E C Friedberg

文献索引：Mutat. Res. 245(4) , 287-92, (1990)

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摘要

Synchronously dividing haploid yeast cells were UV-irradiated in various stages of the cell cycle after release from alpha-factor arrest. In confirmation of earlier results (Chanet et al., 1973), in wild-type strains G1/S phase cells were found to be the most sensitive and late S/G2 cells the most resistant. Stationary-phase (G0) cells were significantly more UV resistant than G1 cells. Strains defective in nucleotide excision repair lost enhanced resistance in the G2 phase and were most UV-sensitive in the G0 state. Reduced G2 resistance was also observed in rad6 mutants but not in rad9 mutants. After UV-irradiation in G1 phase rad9 mutant cells showed a reduced G1/S phase arrest.

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  • Mating Factor α (...

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