Effect of lithium treatments on the tyrosine-aminopeptidase activities in the rat brain and the pituitary gland.
J M de Gandarias, J Irazusta Astiazaran, A Varona, D Fernández, J Gil, L Casis
文献索引:Arzneimittelforschung 49 , 816-819, (1999)
全文:HTML全文
摘要
Lithium (CAS 7439-93-2) is being utilized widely for the treatment of manic-depressive illness. However, the neurochemical mechanism of the ion action still remains relatively obscure. In the present work, the effect of acute lithium administration on soluble and membrane-bound enkephalin-degrading tyrosine-aminopeptidase activities in discrete brain areas and the pituitary gland is described. Tyrosine-aminopeptidase activities have been measured fluorometrically using Tyr-beta-naphthylamide as substrate and puromycin as selective inhibitor of one of the two membrane activities. Soluble and membrane-bound puromycin-insensitive Tyr-aminopeptidase activities are greater in the pituitary gland after treatment with 5 and 10 meq/kg of lithium. It is suggested that these enzyme activities could play a part in the lithium action mechanism.
相关化合物
相关文献:
2001-03-01
[Phytochemistry 56 , 523-527, (2001)]
1996-01-01
[Life Sci. 59 , 1097-1101, (1996)]