2-Acylamino-5-chlorobenzophenones with enhanced selectivity towards malaria parasites.
Swetlana Heinrich, Mirko Altenkämper, Benjamin Bechem, Johann Perruchon, Regina Ortmann, Hans-Martin Dahse, Yulin Wang, Michael Lanzer, Martin Schlitzer
文献索引:Eur. J. Med. Chem. 46(4) , 1331-42, (2011)
全文:HTML全文
摘要
Previously we described a series of 5-acylaminobenzophenones with considerable antimalarial activity. Unfortunately, most compounds also displayed high cytotoxicity resulting in low selectivity towards malaria parasites. Through the replacement of the 5-acylamino moiety by simple chlorine and further modifications of the 2-acylamino residue we could obtain inhibitors with improved selectivity towards malaria parasites combined with an acceptable reduction of antimalarial activity.Copyright © 2011 Elsevier Masson SAS. All rights reserved.
相关化合物
相关文献:
[J. Chromatogr. A. 615(2) , 365-8, (1993)]
[J. Chromatogr. A. 578(1) , 146-51, (1992)]
Studies on organic single crystal: 2-amino-5-chlorobenzophenone (2A-5CB). Babu, R. Ramesh, et al.
[J. Cryst. Growth 265.1 , 290-295, (2004)]
Simultaneous HPLC Determination of Chlordiazepoxide and Mebeverine HCl in the Presence of Their Degradation Products and Impurities. El-Shaheny, Rania N., and Fathalla F. Belal.
[J. Chem. 2015 , 1-9, (2015)]