Application of Nazarov type electrocyclization to access [6,5,6] and [6,5,5] core embedded new polycycles: an easy entry to tetrahydrofluorene scaffolds related to Taiwaniaquinoids and C-nor-D homosteroids.
Ritesh Singh, Gautam Panda
文献索引:Org. Biomol. Chem. 9 , 4782, (2011)
全文:HTML全文
摘要
An easy, efficient and concise approach to tetrahydrofluorene [6,5,6]ABC tricyclic core embedded new polycycles has been achieved under relatively mild and catalytic Nazarov type electrocyclization conditions, using 2 mol% of Sc(OTf)(3) in anhydrous DCM (dichloromethane) at room temperature, with high yields. The generality of the reaction has been illustrated by synthesizing diverse polycycles embedded with rare heterotricyclic [6,5,5]ABC skeletons.
相关化合物
相关文献:
2011-04-28
[Med. Chem. 54 , 2668, (2011)]
2011-05-02
[ChemMedChem 6 , 904, (2011)]
Atlan, V.; et al.
[Chem. Commun. (Camb.) 7 , 918, (2003)]