BioMed Research International 2015-01-01

Effects of Sucroferric Oxyhydroxide Compared to Lanthanum Carbonate and Sevelamer Carbonate on Phosphate Homeostasis and Vascular Calcifications in a Rat Model of Chronic Kidney Failure.

Olivier Phan, Marc Maillard, Hartmut H Malluche, Jean-Christophe Stehle, Felix Funk, Michel Burnier

文献索引:Biomed Res. Int. 2015 , 515606, (2015)

全文:HTML全文

摘要

Elevated serum phosphorus, calcium, and fibroblast growth factor 23 (FGF23) levels are associated with cardiovascular disease in chronic renal disease. This study evaluated the effects of sucroferric oxyhydroxide (PA21), a new iron-based phosphate binder, versus lanthanum carbonate (La) and sevelamer carbonate (Se), on serum FGF23, phosphorus, calcium, and intact parathyroid hormone (iPTH) concentrations, and the development of vascular calcification in adenine-induced chronic renal failure (CRF) rats. After induction of CRF, renal function was significantly impaired in all groups: uremic rats developed severe hyperphosphatemia, and serum iPTH increased significantly. All uremic rats (except controls) then received phosphate binders for 4 weeks. Hyperphosphatemia and increased serum iPTH were controlled to a similar extent in all phosphate binder-treatment groups. Only sucroferric oxyhydroxide was associated with significantly decreased FGF23. Vascular calcifications of the thoracic aorta were decreased by all three phosphate binders. Calcifications were better prevented at the superior part of the thoracic and abdominal aorta in the PA21 treated rats. In adenine-induced CRF rats, sucroferric oxyhydroxide was as effective as La and Se in controlling hyperphosphatemia, secondary hyperparathyroidism, and vascular calcifications. The role of FGF23 in calcification remains to be confirmed.


相关化合物

  • 镧粉
  • 肌酐
  • 碳酸镧

相关文献:

Magnesium-deficient high-fat diet: effects on adiposity, lipid profile and insulin sensitivity in growing rats.

2014-10-01

[Clin. Nutr. 33(5) , 879-88, (2014)]

Nanodisco balls: control over surface versus core loading of diagnostically active nanocrystals into polymer nanoparticles.

2014-09-23

[ACS Nano 8(9) , 9143-53, (2014)]

The role of amorphous precursors in the crystallization of La and Nd carbonates.

2015-07-28

[Nanoscale 7 , 12166-79, (2015)]

[Reactive oxygen forms and Ca ions as possible intermediaries under the induction of heat resistance of plant cells by jasmonic acid].

[Ukr. Biokhim. Zh. 85(3) , 62-8, (2013)]

Lanthanum induced primary neuronal apoptosis through mitochondrial dysfunction modulated by Ca²⁺ and Bcl-2 family.

2013-04-01

[Biol. Trace Elem. Res. 152(1) , 125-34, (2013)]

更多文献...