Non-hinge-binding pyrazolo[1,5-a]pyrimidines as potent B-Raf kinase inhibitors

Dan M. Berger, Nancy Torres, Minu Dutia, Dennis Powell, Greg Ciszewski, Ariamala Gopalsamy, Jeremy I. Levin, Kyung-Hee Kim, Weixin Xu, James Wilhelm, YongBo Hu, Karen Collins, Larry Feldberg, Steven Kim, Eileen Frommer, Donald Wojciechowicz, Robert Mallon, Dan M. Berger, Nancy Torres, Minu Dutia, Dennis Powell, Greg Ciszewski, Ariamala Gopalsamy, Jeremy I. Levin, Kyung-Hee Kim, Weixin Xu, James Wilhelm, YongBo Hu, Karen Collins, Larry Feldberg, Steven Kim, Eileen Frommer, Donald Wojciechowicz, Robert Mallon

文献索引：Bioorg. Med. Chem. Lett. 19(23) , 6519-23, (2009)

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摘要

Optimization of initial lead compound 1 provided a series of pyrazolo[1,5- a]pyrimidines 2 as potent B-Raf kinase inhibitors.