Journal of Combinatorial Chemistry
2010-01-01
Synthesis of pyrazolo[5,1-d][1,2,3,5]tetrazine-4(3H)-ones.
Yaojun Gao, Yulin Lam
文献索引:J. Comb. Chem. 12(1) , 69-74, (2010)
全文:HTML全文
摘要
A solid-phase synthesis of 5-aminopyrazole has been developed and applied to the preparation of pyrazolo[5,1-d][1,2,3,5]tetrazine-4(3H)-ones. In this strategy, a one-pot reaction from 5-aminopyrazoles to the pyrazolo[5,1-d][1,2,3,5]tetrazine-4(3H)-ones which provided the compounds in good yields was demonstrated. Using this synthetic strategy, we prepared a representative set of 16 pyrazolo[5,1-d][1,2,3,5]tetrazine-4(3H)-ones.
相关化合物
相关文献:
2011-01-01
[Eur. J. Med. Chem. 46(12) , 5825-32, (2011)]