Acta Pharmaceutica 2008-06-01

N-phthaloyl-glycine-hydroxamic acid as serum iron chelator in rats.

Julija Matijević-Sosa, Ita Samarzija, Lorena Honović, Blazenka Jurisić

文献索引：Acta. Pharm. 58(2) , 231-6, (2008)

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摘要

The aim of this study was to investigate the activity of N-phthaloyl-glycine-hydroxamic acid (Phth-Gly-HA) as a new iron chelator in vivo to be used in iron overload diseases. After intraperitoneal application of Phth-Gly-HA to male rats (1 mg kg(-1) body mass) once a day for seven days, iron serum level decreased by 21%, whereas the iron value dropped by 32% in female rats (1.5 mg kg(-1) body mass). The results indicate that the tested substance has the ability to bind serum iron by complexation. Besides transferrin iron release, mobilization of ferritin iron is also possible.

相关化合物

  • 邻苯二甲酰甘氨酸

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