A practical method for the synthesis of highly enantioenriched trans-1,2-amino alcohols.
James A Birrell, Eric N Jacobsen
文献索引：Org. Lett. 15(12) , 2895-7, (2013)
全文：HTML全文
摘要
A highly enantioselective addition of phenyl carbamate to meso-epoxides has been developed to efficiently generate protected trans-1,2-amino alcohols. This transformation is promoted by an oligomeric (salen)Co-OTf catalyst and has been used to prepare two useful 2-aminocycloalkanol hydrochlorides in enantiopure form on a multigram scale from commercially available starting materials.
相关化合物
相关文献：
Stereochemistry of Aminocyclanols. Synthesis of cis Epimers via Oxazolines. The 2-Aminocyclopentanols*. McCasland GE and Smith DA.
[J. Am. Chem. Soc. 72(5) , 2190-2195, (1950)]
Preparation of antidotes for anticholinesterase poisoning. IV. Synthesis and protective effectiveness of 2'-(cis-and trans-2'-hydroxycyclohexyl) aminoethyl 1-phenylcyclopentanecarboxylate hydrochlorides. Bannard RAB and Parkkari JH.
[Can. J. Chem. 48(9) , 1377-1382, (1970)]