Journal of Pharmacy and Pharmacology 1984-04-01

Preliminary study of the disposition in man of acebutolol and its metabolite, diacetolol, using a new stereoselective hplc method.

M G Sankey, A Gulaid, C M Kaye

文献索引：J. Pharm. Pharmacol. 36(4) , 276-7, (1984)

全文：HTML全文

摘要

A new stereospecific hplc method that is capable of simultaneously quantitating the S-(-)- and R-(+)-enantiomers of acebutolol and its major metabolite, diacetolol, in plasma and urine, is described. When applied to the assay of biological fluids collected during single and chronic oral dosing with acebutolol (Sectral), this procedure failed to reveal any important stereoselectivity in the disposition of either acebutolol or diacetolol in man. This may occur because acebutolol is metabolized by hydrolysis and N-acetylation, whereas the other beta-blockers which exhibit some degree of stereoselective disposition (e.g. metoprolol and propranolol) are primarily metabolized by oxidation.

相关化合物

  • N-(3-乙酰基-4-(2-...

相关文献：

Using supported liquid extraction together with cellobiohydrolase chiral stationary phases-based liquid chromatography with tandem mass spectrometry for enantioselective determination of acebutolol and its active metabolite diacetolol in spiked human plasma.

2009-01-15

[J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 877(3) , 173-80, (2009)]

Acebutolol: a review of its pharmacology, pharmacokinetics, clinical uses, and adverse effects.

1986-01-01

[Pharmacotherapy 6(2) , 45-63, (1986)]

Lack of effect of liver disease on the pharmacokinetics of acebutolol and diacetolol: a single dose study.

1985-01-01

[Biopharm. Drug Dispos. 6(2) , 131-7, (1985)]

Enantioselective high performance liquid chromatographic assay of acebutolol and its active metabolite diacetolol in human serum.

1999-01-01

[Chirality 11(4) , 267-71, (1999)]

Displacement of [3H]dihydroalprenolol binding from rat heart and lung by acebutolol, diacetolol and D-diacetolol.

1983-03-01

[J. Pharm. Pharmacol. 35(3) , 198-9, (1983)]

更多文献...