Hydrogen bond templated 1:1 macrocyclization through an olefin metathesis/hydrogenation sequence.

Andrada Stefania Trita, Thierry Roisnel, Florence Mongin, Floris Chevallier

文献索引：Org. Lett. 15(14) , 3798-801, (2013)

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摘要

The construction of pyridine-containing macrocyclic architectures using a nonmetallic template is described. 4,6-Dichlororesorcinol was used as an exotemplate to self-organize two aza-heterocyclic units by OH···N hydrogen bonds. Subsequent sequential double olefin metathesis/hydrogenation reactions employing a single ruthenium-alkylidene precatalyst open access to macrocyclic molecules.