Bioorganic & Medicinal Chemistry Letters
2005-01-17
Synthesis and SAR of novel 4,5-diarylimidazolines as potent P2X7 receptor antagonists.
Gregory H Merriman, Liang Ma, Patrick Shum, Daniel McGarry, Frank Volz, Jeffrey S Sabol, Alexandre Gross, Zhicheng Zhao, David Rampe, Lin Wang, Friederike Wirtz-Brugger, Bruce A Harris, Douglas Macdonald
文献索引:Bioorg. Med. Chem. Lett. 15(2) , 435-8, (2005)
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摘要
A series of 4,5-diarylimidazoline libraries were prepared using high-throughput solid-phase and microwave techniques. The compounds were evaluated as P2X(7) antagonists and their SAR is described.