Journal of Biological Chemistry 1981-03-10

Conversion of 5,8,11-eicosatrienoic acid to leukotrienes C3 and D3.

S Hammarström

文献索引：J. Biol. Chem. 256 , 2275, (1981)

全文：HTML全文

摘要

5,8,11-Eicosatrienoic acid was converted by mouse mastocytoma cells stimulated with ionophore A23187 to two slow reacting substances. These were characterized by spectroscopy and by chemical and enzymatic degradations as two geometrical isomers of 5-hydroxy-6-S-glutathionyl-7,9,11-eicosatrienoic acid (E,E,Z; leukotriene C3 and E,E,E; 11-trans-leukotriene C3). Corresponding cysteinylglycine compounds (leukotriene D3 and 11-trans leukotriene D3) were obtained from the leukotriene C3 isomers by treatment with kidney gamma-glutamyl transpeptidase. The biological effects of leukotrienes C3 and D3, on the isolated guinea pig ileum, were approximately the same as of leukotrienes derived from arachidonic acid.

相关化合物

  • 白三烯C3

相关文献：

Contractile activities of structural analogs of leukotrienes C and D: necessity of a hydrophobic region.

1981-05-01

[Proc. Natl. Acad. Sci. U. S. A. 78 , 3195, (1981)]

Distribution and metabolism of 3H-labeled leukotriene C3 in the mouse.

1982-01-10

[J. Biol. Chem. 257(1) , 531-5, (1982)]

Metabolism of leukotriene C3 in the guinea pig. Identification of metabolites formed by lung, liver, and kidney.

1981-09-25

[J. Biol. Chem. 256(18) , 9573-8, (1981)]

Contractile activities of several cysteine-containing leukotrienes in the guinea-pig lung strip.

2009-01-01

[Eur. J. Pharmacol. 86(2) , 207-15, (1982)]

Metabolism of leukotriene C3.

1982-01-01

[Adv. Prostaglandin. Thromboxane. Leukot. Res. 9 , 83-101, (1982)]

更多文献...