Biochimica et Biophysica Acta 2009-08-01

Synergistic transmembrane insertion of the heterodimeric PGLa/magainin 2 complex studied by solid-state NMR.

Erik Strandberg, Pierre Tremouilhac, Parvesh Wadhwani, Anne S Ulrich

文献索引：Biochim. Biophys. Acta 1788 , 1667-1679, (2009)

全文：HTML全文

摘要

The skin secretions of amphibians are a rich source of antimicrobial peptides. The two antimicrobial peptides PGLa and magainin 2, isolated from the African frog Xenopus laevis, have been shown to act synergistically by permeabilizing the membranes of microorganisms. In this report, the literature on PGLa is extensively reviewed, with special focus on its synergistically enhanced activity in the presence of magainin 2. Our recent solid state (2)H NMR studies of the orientation of PGLa in lipid membranes alone and in the presence of magainin 2 are described in detail, and some new data from 3,3,3-(2)H(3)-L-alanine labeled PGLa are included in the analysis.

相关化合物

  • Magainin 2
  • PGLA

相关文献：

Trypanosoma cruzi: synergistic cytotoxicity of multiple amphipathic anti-microbial peptides to T. cruzi and potential bacterial hosts.

2010-08-01

[Exp. Parasitol. 125(4) , 342-7, (2010)]

Design and characterization of novel hybrid antimicrobial peptides based on cecropin A, LL-37 and magainin II.

2012-02-01

[Peptides 33(2) , 197-205, (2012)]

Magainins as paradigm for the mode of action of pore forming polypeptides.

1998-11-10

[Biochim. Biophys. Acta 1376 , 391-400, (1998)]

Binding of antibacterial magainin peptides to electrically neutral membranes: thermodynamics and structure.

1999-08-10

[Biochemistry 38 , 10377, (1999)]

A critical comparison of the hemolytic and fungicidal activities of cationic antimicrobial peptides.

1999-04-23

[FEBS Lett. 449 , 105, (1999)]

更多文献...