Facile synthesis of phosphonamidate- and phosphonate-linked phosphonopeptides.
Nanyan Fu, Qihan Zhang, Lifang Duan, Jiaxi Xu
文献索引：J. Pept. Sci. 12(4) , 303-9, (2006)
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摘要
A direct method for the preparation of phosphonamidate- and phosphonate-linked phosphonopeptides has been developed. Using this method, both phosphonopeptides were prepared in acceptable yields directly from simple and commercially available chemicals in one-pot reactions of benzyl carbamate, aldehydes, and methyl dichlorophosphite, followed by aminolysis with amino acid esters or alcoholysis with hydroxy esters.Copyright 2006 European Peptide Society and John Wiley & Sons, Ltd.
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