ACS Chemical Biology 2014-04-18

Bright building blocks for chemical biology.

Luke D Lavis, Ronald T Raines

文献索引：ACS Chem. Biol. 9(4) , 855-66, (2014)

全文：HTML全文

摘要

Small-molecule fluorophores manifest the ability of chemistry to solve problems in biology. As we noted in a previous review (Lavis, L. D.; Raines, R. T. ACS Chem. Biol. 2008, 3, 142-155), the extant collection of fluorescent probes is built on a modest set of "core" scaffolds that evolved during a century of academic and industrial research. Here, we survey traditional and modern synthetic routes to small-molecule fluorophores and highlight recent biological insights attained with customized fluorescent probes. Our intent is to inspire the design and creation of new high-precision tools that empower chemical biologists.

相关化合物

  • 4,5-二甲氧基-2-硝...

相关文献：

Caged vanilloid ligands for activation of TRPV1 receptors by 1- and 2-photon excitation.

2006-04-18

[Biochemistry 45(15) , 4915-26, (2006)]

Spatially discrete, light-driven protein expression.

2002-12-01

[Chem. Biol. 9(12) , 1347-53, (2002)]

Model compounds of caged capsaicin: design, synthesis, and photoreactivity.

2003-11-14

[J. Org. Chem. 68(23) , 9100-4, (2003)]

Light-mediated in cell downregulation of G-quadruplex-containing genes using a photo-caged ligand.

2013-10-04

[Chem. Commun. (Camb.) 49(76) , 8453-5, (2013)]

Caged AG10: new tools for spatially predefined mitochondrial uncoupling.

2009-05-01

[Mol. Biosyst. 5(5) , 450-7, (2009)]

更多文献...