Il Farmaco 2000-02-01

An efficient method for the synthesis of sulbactam pivoxil.

L S Changov, B K Vassileva, M N Confino, N N Agapova

文献索引：Il Farmaco 55(2) , 134-5, (2000)

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摘要

Sulbactam pivoxil, a prodrug of the beta-lactamase inhibitor sulbactam, was prepared in high yield by reacting the sodium salt of sulbactam with chloromethyl pivalate in a polar solvent, then diluting the reaction mixture with water and isolating the product by filtration. Dimethyl sulfoxide was found to be the solvent of choice among several aprotic organic solvents.

相关化合物

  • 特戊酸氯甲酯

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