Continuous synthesis and purification by direct coupling of a flow reactor with simulated moving-bed chromatography.
Alexander G O'Brien, Zoltán Horváth, François Lévesque, Ju Weon Lee, Andreas Seidel-Morgenstern, Peter H Seeberger
文献索引：Angew. Chem. Int. Ed. Engl. 51(28) , 7028-30, (2012)
全文：HTML全文
摘要
Continuous synthesis meets continuous purification to produce pure products from crude reaction mixtures. In the nucleophilic aromatic substitution of 2,4-difluoronitrobenzene with morpholine the desired monosubstituted product can be continuously separated from the byproducts in a purity of over 99 % by coupling a flow reactor to a simulated moving bed (SMB) chromatography module.Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
相关化合物
相关文献：
A direct synthesis of 2-arylpropenoic acid esters having nitro groups in the aromatic ring: a short synthesis of (±)-coerulescine and (±)-horsfiline. Selvakumar N, et al.
[Tetrahedron Lett. 43(50) , 9175-78, (2002)]
A solid phase traceless synthesis of 2-arylaminobenzimidazoles. Krchnák V, et al.
[Tetrahedron Lett. 42(9) , 1627-30, (2001)]
1990-09-01
[Biol. Chem. Hoppe-Seyler 371(9) , 861-4, (1990)]