Organic Letters 2007-02-15

One-step synthesis of alpha-chloro acetophenones from acid chlorides and aryl precursors.

Jonathan Rosen, Dietrich Steinhuebel, Michael Palucki, Ian Davies

文献索引：Org. Lett. 9(4) , 667-9, (2007)

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摘要

A direct and efficient method was developed for the preparation of a variety of substituted acetophenone derivatives from readily available arene precursors and acid chlorides. This method has significant generality and affords access to substitution patterns on aryl rings not directly achievable by Friedel-Crafts chemistry. [reaction: see text].

相关化合物

  • 4-氯苯氧基乙酰氯

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